|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic loci link adipose and insulin biology to body fat distribution.
|
25673412 |
2015 |
|
Waist Circumference
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic loci link adipose and insulin biology to body fat distribution.
|
25673412 |
2015 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
TRIM66 protein content was highest in NSCLC cell line A549, compared with BEAS-2B, it showed that the TRIM66-siRNA group lung cancer cell proliferation was significantly reduced after knockdown of TRIM66, and knockdown of TRIM66 also suppressed invasion, migration and clonogenic ability of A549 cells.
|
29929749 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Loss-of-function experiments by RNA interfering knockdown of TRIM66 showed that TRIM66 inhibition significantly reduced the proliferation, colony formation, and invasion of HCC cells, whereas gain-of-function by overexpression of TRIM66 exhibited the opposite effect.
|
30710548 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of TRIM66 inhibits cell proliferation, migration and invasion in colorectal cancer through JAK2/STAT3 pathway.
|
31472144 |
2019 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
|
28443625 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
TRIM66 is highly expressed in HCC, which is positively correlated with tumor stage, lymph node metastasis and distant metastasis of HCC patients.
|
30915743 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The high TRIM66 expression closely associated with lymph node metastasis and TNM stage in NSCLC patients (P< 0.05).
|
28946563 |
2017 |
|
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High TRIM66 expression was correlated with high rate of local recurrence and lung metastasis, and short survival time.
|
26247633 |
2015 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRIM66 protein content was highest in NSCLC cell line A549, compared with BEAS-2B, it showed that the TRIM66-siRNA group lung cancer cell proliferation was significantly reduced after knockdown of TRIM66, and knockdown of TRIM66 also suppressed invasion, migration and clonogenic ability of A549 cells.
|
29929749 |
2018 |
|
Physical Activity Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
|
28448500 |
2017 |
|
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
MicroRNA-451a inhibits the growth and invasion of osteosarcoma cell lines through targeting tripartite motif-containing 66.
|
31434545 |
2019 |
|
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, TRIM66 may act as an oncogene through suppressing apoptosis pathway and promoting TGF-β signaling in osteosarcoma carcinogenesis.
|
26247633 |
2015 |
|
Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
MicroRNA-451a inhibits the growth and invasion of osteosarcoma cell lines through targeting tripartite motif-containing 66.
|
31434545 |
2019 |
|
Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, TRIM66 may act as an oncogene through suppressing apoptosis pathway and promoting TGF-β signaling in osteosarcoma carcinogenesis.
|
26247633 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Silence TRIM66 expression suppressed NSCLC cell proliferation, invasion, and migration.
|
29929749 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
TRIM66 can be serve as an important molecular marker for predicting the prognosis in NSCLC patients.
|
28946563 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression of TATDN1, miR-451 and TRIM66 in NSCLC tissues and cell lines were detected by qRT-PCR or western blot.
|
30481109 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Furthermore, TRIM66 knockdown markedly inhibited tumor growth in a mouse xenograft model.
|
31472144 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
High expression of TRIM66 was positively correlated with tumor stage, lymph node metastasis and distant metastasis, whereas not correlated with age and sex of HCC patients.
|
30915743 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Additionally, in vivo experiments using a xenograft tumor model showed that TRIM66 knockdown blunted the tumorigenicity of HCC cells associated with downregulation of β-catenin expression.
|
30710548 |
2019 |